Why do kids tend to have milder COVID? This new study gives us a clue

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Joanna Groom, Walter and Eliza Hall Institute

A new Australian study, published overnight in Nature Communications, gives an insight into how kids’ immune systems respond to infection with SARS-CoV-2, the virus that causes COVID-19.

It’s the first study, to my knowledge, that directly compares children and adults with mild COVID.

Children are less likely to become infected, and when they are, they are more likely to be asymptomatic. This is in contrast to other viral and respiratory infections that are more prevalent among young people.

This new research helps explain how kids’ immune systems work when confronted with the coronavirus — and gives us clues as to why they generally seem to fare better than adults.

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Worried about your child getting coronavirus? Here’s what you need to know

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The kids (immune systems) are alright

The researchers studied 48 kids, mostly in primary school, across 28 households during Melbourne’s second wave. All children were exposed to the coronavirus in their households by infected parents.

This study focused on the “innate” immune response in children, which forms the early part of the immune system’s attack on a virus (or bacteria, or other pathogens). The innate immune system plays an important role in viral protection before the body raises antibodies.

The study found there were dynamic changes in kids’ early immune responses, compared with coronavirus-infected adults.

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Explainer: what is the immune system?

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One key innate immune cell that was elevated in children exposed to the virus was a type of white blood cell called “neutrophils”. These cells patrol the body for infections. When they discover a pathogen, they have a unique ability to respond by trapping and killing the invading pathogen (in this case, the coronavirus).

This role may ensure the virus is not able to infect more cells. This potentially decreases the “viral load”, basically the amount of virus in your body.

The researchers looked at neutrophils, a type of white blood cell.
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For some of the kids in the study, the early immune responses kept the viral load so low that they never returned a positive test, despite being tested throughout the study and having been exposed to coronavirus.

One strength of this study is that it was “longitudinal”, meaning it studied families over time, rather than simply at one point in time. The researchers looked at immune responses of the families just after their exposure to the virus, and returned more than 30 days later to see what had changed. This allowed them to identify the key changes induced because of the exposure to the virus.

Kids vs adults

A key question arising from this research is: why did the kids show such strong immune responses, resulting in few or no symptoms, while their parents were very ill?

It’s a difficult question to answer, at least so far. But the key differences in responses are likely to lie in the early responses of the immune system.

There is some previous research that might give some clues.

One theory surrounds the fact that children have less of the receptors called “ACE2” in their respiratory tract. These receptors are the pathway of entry for the virus into our cells. In theory, less ACE2 receptors mean less chance for the virus to break in and infect our cells. Virus’ don’t survive for very long outside a cell. With less ACE2 receptors, it may give more time for the innate immune cells to control the virus as much as it can while waiting for other immune cells to come along and help.

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Read more:
ACE2: the molecule that helps coronavirus invade your cells

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Another possibility relates to “interferons”, which are alert signals released by cells to tell the body there’s a virus around. Researchers think higher levels of interferons during the early phase of an infection are very important for controlling coronavirus. Potentially, interferons may help promote the increased neutrophils that were seen in children, compared with lower numbers observed in adults.

The wide range of symptoms in COVID are intriguing and frustrating at the same time. Conventional wisdom was that kids are more prone to getting sick with respiratory illnesses than adults — just ask any parent! But with COVID it seems to be the opposite.

Often when we think we’ve nailed down a specific mechanism as to how this new virus works and how our bodies respond to it, it turns out such a mechanism is different across different people. We can see this in the huge range of symptoms that different people display — some get a runny nose, others get a cough, and others suffer extreme exhaustion and respiratory distress or develop “long COVID”, in which symptoms drag on for months.

Coronavirus is still keeping immunologists on their toes. Studies like this one help solve some of the puzzle in understanding who’s at most at risk of severe disease and why.

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Read more:
Five life lessons from your immune system

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Joanna Groom, Laboratory Head, Walter and Eliza Hall Institute

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Muslim Extremists Suspected in Death of Christian Worker in India

Christian in Jharkhand state may have been slain during Islamic festival.

NEW DELHI, September 28 (CDN) — Family members of a Christian worker who was found dead in a Muslim area in Jharkhand state a day after the Islamic Eid festival said they suspect he may have been murdered by local residents.

The body of Shravan Kumar, who had worked with the Gospel Echoing Missionary Society, was found lying in a well near the Idgah Mosque in Garhwa town in the wee hours of Sept. 13, a close relative of the deceased told Compass by phone.

Kumar, 31, lived in Pratapgarh district in neighboring Uttar Pradesh state. He left for Garhwa, 65 kilometers (40 miles) from his house, saying he wanted to see a colleague there on Sept 10.

“But neither did he visit the colleague, nor did he get back home,” said the relative.

On Sept. 15, a family member went to Garhwa looking for him. He found his picture in an advertisement police had placed in a local newspaper in an effort to identify the body.

“When Kumar’s body was handed over to the family, it was beyond recognition; it had swollen,” said the relative.

Later, the family member went to the well in Garhwa where the body was found. Local youths who pulled Kumar’s body from the well the morning of Sept. 13 informed the family member that they noticed injuries on his face and around his neck. Police were immediately informed, but officers did not arrive until 10 p.m.

“Kumar had lived in a rented house in Garhwa a few years ago, and on the morning of Sept. 12 he visited his old landlord and mentioned that he planned to preach in the Idgah Mosque area,” said the source, adding that Kumar’s family suspected “that he preached to the Muslims on the Eid festival, and as a result he was killed and thrown in the well.”

A police spokesman, however, said he refused to believe that Kumar was murdered. Deputy Superintendent of Police Ashok Kumar Singh told Compass that “as of now” police were not exploring any possibility of a crime.

“The post-mortem report says there was no injury mark on his body, and he died by drowning,” Singh said.

In 1998, Kumar had received a head injury after suspected Hindu nationalist extremists hit him with a rod in Sitamani in neighbouring Bihar, the relative said.

“Since then, he had been suffering from a mild psychological ailment,” he added. “If he did not take his daily medicine, he would get a little disturbed and begin to preach to non-Christians aggressively. This is what may have happened on Sept. 12 when he preached in the Muslim area.”

Kumar, who became a Christian from a Hindu background in 1997, held prayer meetings in his house shortly after his conversion against the wishes of local Hindu nationalists, the relative added.

The religious atmosphere in India was tense at the time of his death. On Sept. 13, Muslim mobs burned a Christian school and a church, both belonging to the Church of North India (CNI), in the Muslim-majority Kashmir region in the state of Jammu and Kashmir. No students or staff members of the school were hurt, but at least five Muslims died and more than 50 were injured as security officers opened fire at the mob to prevent the burning of the school.

Also, on Aug. 13 Muslims attempted to burn a CNI hospital in Jammu and Kashmir’s Anantnag district, but security forces managed to prevent it. In a separate incident the same day and in the same state, a mob vandalized the Catholic-run Good Shepherd High School in Pulwama district.

In a similar incident the same day, Muslims in Malerkotla town in northern Punjab state burned the furniture of a CNI church.

These incidents took place after the Quran was allegedly desecrated in the United States. Although Florida Pastor Terry Jones had withdrawn the threat to burn the Quran to mark the anniversary of the 9/11 attacks, Iranian government-run news channel Press TV showed dubious clips of the Quran being torn in the US.

Kumar’s family fears that the police will overlook the available clues indicating the role of local Muslims and instead claim that he committed suicide.

“No one who knew Kumar can believe that he could have committed suicide,” said the relative. “Although he was psychologically unwell, he always faced life’s problems boldly.”

Kumar, the sole bread winner in the family, is survived by a 25-year-old wife and a 5-year-old daughter.

According to the 2001 Census, Jharkhand has a population of around 27 million, out of which 4.06 percent are Christian. Muslims account for close to 14 percent of the state’s population.

Report from Compass Direct News

New Dimension in India’s Anti-Christian Violence Feared

Concern grows that Hindu terrorists could become more apt to target Christians.

PUNE, India, November 5 (CDN) — After the recent arrests of numerous Hindu terrorists for exploding bombs, authorities increasingly view Hindu rightwing extremists as a threat not only to Muslim and Christian minorities but also to national security.

Historically Hindu terrorist groups have traded blows with India’s Muslim extremists, but because of a perceived threat from Christianity – as one Hindu extremist leader expressed to Compass – many analysts believe Hindu terrorists increasingly pose dangers to Christians as well.

Police in Goa state arrested two members of Hindu terrorist group Sanatan Sanstha (Eternal Organization) on Saturday (Oct. 31) for their alleged role in an explosion that took place near a church in Margao on Oct 16. Christians, which make up more than 25 percent of the 1.3 million people in Goa, were apparently not the target of the explosion, which occurred accidently when two members of the Sanatan Sanstha were trying to transport explosives to a nearby location on the eve of the Diwali Hindu festival, according to DNA newspaper.

Nevertheless, the incident served as a wake-up call to Christian leaders and others who fear Hindu terrorists could take greater aim at the Christian community. John Dayal, secretary general of the All India Christian Council (AICC), said that while terrorism was not new for rightwing groups, some of the extremist groups had “metamorphosed into fully fledged terrorism squads on classical lines – cells with local leaders, supply lines, bomb-making experts, and clear linkage with the intellectuals and motivators in the RSS [Hindu extremist Rashtriya Swayamsevak Sangh] hierarchy.”

Suresh Khairnar, a civil rights activist who has conducted nearly 100 fact-finding trips on communal incidents, told Compass that Muslims may be the main target of Hindu terrorist outfits, but “there is no doubt that they pose a threat to the Christians also.” He added that these Hindu groups also launch attacks on Hindus from time to time – masquerading as Islamist groups to create communal unrest, as well as to confuse investigating agencies.

Asghar Ali Engineer, chairman of the Centre for Study of Society and Secularism in Mumbai, concurred that Christians have increasingly become a secondary target for rightwing Hindu terrorists behind Muslims, who form 13.4 percent of the population.

“Christians, on the other hand, are only 2.3 percent,” said Engineer. “And because of their engagement with education, medicine and social work, it is difficult to promote anti-Christian sentiments.”

A former inspector general of police of Maharashtra, S.M. Mushrif, also said that while Muslims are the prime target of Hindu terrorists, attacking Christians also helps the Hindu assailants to portray themselves as “working for a Hindu cause.”

Members of suspected terror groups are known to have attacked Christians. On June 27, Shailendra Chauhan, alias Uday Singh – suspected to be a close aide of Sadhvi Pragya Singh Thakur, the prime suspect in a September 2008 blast in Malegaon, Maharashtra – was arrested for allegedly killing a Christian priest in Noida, a satellite town of Delhi. The 25-year-old Chauhan was also accused of vandalizing a church building in Sangam Vihar in Delhi in October 2008, according to The Times of India.

The AICC’s Dayal added that Islamic groups are the immediate target of Hindu terrorist groups, “but once the terror gangs of Hindutva [Hindu nationalist ideology] taste blood, it is easy to predict that they will swing into action against any perceived enemy target.”

How Alleged Terrorist Group Views Christians

The Anti-Terrorism Squad (ATS) of Mumbai is investigating powerful bomb blasts in Malegaon town, Maharashtra, allegedly carried out by members of the Hindu nationalist Abhinav Bharat (Pride of India) in September 2008. Compass spoke with the president of Abhinav Bharat about the alleged terrorist group’s attitude toward Christians.

The Malegaon blasts near a mosque killed six people and injured more than 100. The ATS arrested 11 people, including a serving officer of the Indian Army, from the Abhinav Bharat and other rightwing outfits.

The president of the Abhinav Bharat, Himani Savarkar, told Compass that members of her organization had been falsely accused, saying “The government is lying about their involvement. There is collusion between Muslims and the government.”

Asked if only Muslims were a threat to Hindus, she said, “There is danger from both Muslims and Christians, because of conversions and terrorism.”

Conversion represents a threat in that people converting to Islam change their loyalties from India to Mecca, while the loyalties of converts to Christianity shift from India to the Pope, Savarkar said. She also spoke of a more direct threat in Christianity – “Muslims want to kill the kafirs [unbelievers], and even Jesus asks in the Bible to kill all those who do not believe in Him” – and it is not known how many other Hindu extremists share this fallacy.

The number of Hindus, she added, “is slowly reducing, and one day we will become a minority in our own nation. We do not have any other nation.”

Savarkar, niece of Nathuram Godse, a Hindu nationalist who killed Indian independence leader Mahatma Gandhi in January 1948, said that in her view the main reasons people convert away from Hinduism are poverty and illiteracy.

“They do not know what they are doing,” she said. “We have to awaken Hindus. Hindus need to be made aware of the threats.”

Violent Despair

The use of bombs is a sign of frustration among extremists, said civil rights activist Khairnar, referring to the two successive defeats of the Bharatiya Janata Party (BJP), political wing of the Rashtriya Swayamsevak Sangh (RSS), India’s chief Hindu nationalist conglomerate. The BJP, which ruled the federal government from 1998 to 2004, has lost both the 2004 and 2009 general elections.

“They are now exploding bombs because they know they cannot succeed democratically,” he said, though he added that bomb-making per se was not a new development. “Even Nathuram Godse, the killer of Mahatma Gandhi, launched several bomb attacks before finally succeeding in assassinating him.”

In the case of the Malegaon blasts, Dayal said that the involvement of Hindu religious leaders and former army personnel indicated that terror attacks by rightwing Hindu groups were well planned. Security analysts warn that the extremist groups must be prevented from graduating to bigger terror groups.

On Oct. 21, the Mumbai Mirror daily quoted an ATS officer as saying Hindu extremist groups “are putting up a mild face as an organization while their members are detonating bombs. It’s only a matter of time before they begin to acquire better technology and more lethal bombs. Their influence is growing; there are several politicians and even ex-policemen who owe allegiance to them. They can be dangerous if not stopped now.”

O.P. Bali, former director general of police of Maharashtra, told Compass that until 2003, the year he retired, extreme Hindu nationalist groups like the Bajrang Dal mainly used weapons like sticks, tridents and knives.

“Bomb-making is a newer development, and they are still learning,” Bali said. “Considering the way some local Islamist groups have graduated from making and detonating of small bombs to bigger ones, the efforts of rightwing groups must be nipped in the bud.”

Hindu/Muslim violence has a long history. In 1947, when India became politically independent, British colonial India was divided into “Hindu-majority” India and “Muslim-majority” Pakistan. The partition resulted in the killing of around 1 million people – Hindu, Sikh and Muslim – in violent clashes mainly during the mass migration of around 14.5 million people from India to Pakistan and vice versa.

Engineer said the common notion that increasing modernization in India would put a halt to the growth of extremist groups was mistaken.

“Extremism is a reaction to modernization, and therefore such groups will grow even bigger in the future.”

Dayal seconded Engineer, saying the rightwing extremist groups were trying to keep pace with Islamist groups.

“Fortunately, in most areas, government vigilance, civil society and good relations between communities have kept these terror groups at the margins,” Dayal said. “But with the growth of parties that use identity-based divisive issues such as the Maharashtra Navnirman Sena party, with the apathy of government in BJP-ruled states, and with the middle-class support base for them, I fear such Hindutva terror groups may grow. That has been the historical experience in Western Europe and elsewhere.”

When suspects in the Malegaon blast were formally charged in January 2009, ATS officials told the court that the alleged terrorists’ goal was formation of a Hindu nation – and that the suspects planned to approach Israeli intelligence for help in combating Muslim extremists if the need arose, according to a Jan. 21 article in The Hindu.

Following numerous arrests, The Times of India daily on Oct. 21 quoted senior police officials as saying that Maharashtra was fast becoming a “hub of rightwing organizations’ terror activities.”

“The youth are being indoctrinated by fundamentalist organizations,” an officer told the daily. “The state should act quickly to control rightwing terror.”

Report from Compass Direct News 

New, More Dangerous Hindu Extremist Groups Emerge in India

Christians concerned as rightwing factions splinter to form militant outfits.

PUNE, India, October 29 (CDN) — After more than a decade of severe persecution, India’s Christian minority is growing increasingly concerned over the mushrooming of newer and deadlier Hindu extremist groups.

Gone are the days when Christians had to watch out only for the Vishwa Hindu Parishad (World Hindu Council) and its youth wing, Bajrang Dal, which are closely linked with the most influential Hindu extremist umbrella organization, the Rashtriya Swayamsevak Sangh (RSS). With voter support faltering for the RSS’s political wing, the Bharatiya Janata Party (BJP), moderate and extremist sections within the Hindu nationalist movement are blaming each other, and militant splinter groups have emerged.

Claiming to be breakaway factions of the RSS, new groups with even more extreme ideology are surfacing. The Abhinav Bharat (Pride of India), the Rashtriya Jagran Manch (National Revival Forum), the Sri Ram Sene (Army of god Rama), the Hindu Dharam Sena (Army for Hindu Religion) and the Sanatan Sanstha (Eternal Organization) have launched numerous violent attacks on Christian and Muslim minorities.

The Sri Ram Sene was one of the most active groups that launched a series of attacks on Christians and their property in and around Mangalore city in the southern state of Karnataka in August-September 2008, according to a report, “The Ugly Face of Sangh Parivar,” published by the People’s Union of Civil Liberties (PUCL), in March 2009. In Jabalpur city in the central state of Madhya Pradesh, suspected extremists from the Abhinav Bharat attacked the Rhema Gospel Church on Sept. 28, according to the Global Council of Indian Christians. They had earlier attacked Pastor Sam Oommen and his family in the same city on Aug. 3.

The Hindu Dharam Sena has become especially terrifying for Christians in Jabalpur. Between 2006 and 2008, Jabalpur was plagued by at least three anti-Christian attacks every month, according to The Caravan magazine. In the western state of Gujarat and other parts of the country, the Rashtriya Jagran Manch has also violently attacked Christians, according to news website Counter Currents.

At an ecumenical meeting held in New Delhi on Saturday (Oct. 24), the secretary general of the Catholic Bishops’ Conference of India, Archbishop Stanislaus Fernandes, said the rise of fundamentalism was “seriously worrying” the church in India. The meeting was held to discuss prospects for immediate enactment of federal legislation to counter religious extremism with the proposed Communal Violence (Prevention, Control and Rehabilitation of Victims) Bill.

RSS ‘Too Mild’

The new groups, formed mostly by former members of RSS-connected outfits, find the Hindu nationalist conglomerate too “mild” to be able to create a nation with Hindu supremacy.

The Sri Ram Sene, mainly active in south India, was started by Pramod Muthalik after he was expelled in 2007 from the Bajrang Dal, one of the most radical groups in the RSS family, for being an extremist, according to the daily newspaper DNA. The Hindu Dharam Sena was started by Yogesh Agarwal, former worker of the Dharam Jagran Vibhag (Religion Revival Department) of the RSS, also in 2007, as he felt “the RSS did not believe in violence,” according to The Caravan. He had earlier launched the Dharam Sena, an offshoot of the RSS, in Madhya Pradesh and neighboring Chhattisgarh state in 2006.

The founding members of the Abhinav Bharat, which was started in Pune in 2006, also believe that the RSS is not militant enough. Outlook magazine notes that its members were planning to kill top leaders of the RSS for their inability to implement Hindu extremist ideology. The Rashtriya Jagran Manch, also a breakaway group of the RSS founded in 2007, has close links with the Abhinav Bharat.

Based out of Goa, a western state with a substantial number of Christians, the Sanatan Sanstha provides the ideological base for Hindu militant groups. It has close links with the Sri Ram Sene and publishes a periodical, Sanatan Prabhat, which occasionally spews hate against Christians.

Media reports warn of tensions due to the recent spurt in activity of the splinter groups.

“The hardliners are now getting into more extreme activities,” The Times of India daily quoted V.N. Deshmukh, former joint director of India’s Intelligence Bureau, as saying on Oct. 21.

The most extremist sections are disillusioned with the way the RSS is functioning, said Mumbai-based Irfan Engineer, Director of the Institute of Peace and Conflict Studies. Most RSS cadres were mobilized with an ideology that called for elimination of minorities, mainly Muslims and Christians, he told Compass, adding that many of them were highly disappointed with the way the movement was being led.

He said the BJP was restricted when it led a coalition government at the federal level from 1998 to 2004, keeping it from effectively working towards a Hindu nation. A majority of the BJP’s allies in the National Democratic Alliance were not Hindu nationalists.

“One section of the [Hindu nationalist] movement believes in acquiring state power by participating in parliamentary democracy, and the other wants to create a Hindu nation by violent means,” Engineer said.

It is believed that the divide within the RSS family may deepen even further.

Analysts believe that Hindu nationalism is losing relevance in national politics, as was evident in the two successive defeats of the BJP in the 2004 and 2009 general elections. Consequently, the RSS and the BJP may distance themselves from the hard-line ideology or make it sound more inclusive and less militant.

After this year’s elections, the RSS increasingly has begun to talk about the threat China poses to India and the need for development in rural areas, instead of its pet issues like Islamist terrorism and Christian conversions. This has disappointed sections of the highly charged cadres even more, and the splintering may accelerate.

For the next few years, “we will see more new names and new faces but with the same ideology and inspiration,” said Anwar Rajan, secretary of the PUCL in Pune.

Whether the new groups truly have no connection with the RSS is not fully known – that appearance may be an RSS strategy to evade legal action, said Dr. Asghar Ali Engineer, chairman of the Centre for Study of Society and Secularism in Mumbai.

He said relations between the RSS and the new groups can be compared with the ones between Maoist (extreme Marxist) rebels and the Communist Party of India-Marxist (CPI-M) in India. While the CPI-M distances itself from Maoist violence, it speaks for the rebels whenever security forces crack down on them.

At base, the newer rightwing groups surely have the sympathy of the RSS, said Pune-based S.M. Mushrif, former Inspector General of Police in Maharashtra, who has been observing Hindu extremist groups for years.

Report from Compass Direct News