OM85: could bacteria in a capsule protect us from coronavirus and other respiratory infections?

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Peter Sly, The University of Queensland

Scientists around the world are continuing to test countless vaccines and drugs in the hope of finding effective ways to prevent and treat COVID-19.

Among the trials happening in Australia is one my team is about to begin, looking at something called OM85.

OM85 is not a conventional drug, but a combination of molecules extracted from the walls of bacteria that commonly cause respiratory infections.

It’s not available in Australia, but has been used widely in Europe and South America for 40-50 years, commonly under the brand name Broncho-Vaxom.

We’re now looking at its potential to prevent respiratory infections, including COVID-19. But how does it work?

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Read more:
Where are we at with developing a vaccine for coronavirus?

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First, a bit of background

Some of our organs, including the skin, airways and lungs, and gastrointestinal tract, are effectively “open” to the outside world. The cells that line these organs, called mucosal linings, host trillions of bacteria.

These bacteria, known as our “microbiota”, play essential roles in keeping us healthy. This is especially important in the gastrointestinal tract, where the microbiota “train” the immune system.

One of the ways they do this is by providing a continuous stream of signals that move through mucosal linings into the tissues below, where immune cells are found. Specialised immune cells responsible for detecting the invasion of infectious pathogens recognise and respond to these signals.

We now recognise these signals from the microbiota operate as “immune training” agents, helping to keep the front-line defences of the immune system in a state of high alert.

OM85 is made from molecules extracted from the walls of bacteria.
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OM85 is an immune stimulant

OM85 appears to enhance some important aspects of this natural “immune training” process. One way it does this is by stimulating the maturation of regulatory T-cells (called T_regs) in the lymph glands in the upper intestine.

Once they have fully matured, these T_regs can migrate to other mucosal surfaces in the body to bolster local anti-inflammatory defences. This process is especially important in the lungs and airways to prevent respiratory infections.

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Read more:
Explainer: what is the gut microbiota and how does it affect mind and body?

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OM85 signals also leak into our circulation. There they are recognised by cells in the bone marrow, which control the production of other immune cell types.

This results in increased immune cells – both in number and function – that travel to front-line mucosal surfaces, including the airways, to further bolster our immune defences.

We strongly suspect OM85 also influences the makeup of the gastrointestinal microbiome itself, although we know very little about how this happens. This in turn helps to promote the survival of bacterial strains that stimulate the immune system.

What the evidence tells us

OM85 is a preventative, given to those at risk of more severe consequences from respiratory infections, rather than as a treatment of current infections.

Studies have shown OM85 reduces the risk of wheeze linked to infection in infants and schoolchildren.

It also reduces the incidence of
severe flare-ups of chronic obstructive pulmonary disease in adults.

A review of 35 placebo-controlled studies involving 4,060 children concluded that immune stimulants, including OM85, reduced respiratory infections by an average of 40% in susceptible children.

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Read more:
A strong immune system helps ward off colds and flus, but it’s not the only factor

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OM85 has a good safety profile. A small proportion of people may experience some gastro-intestinal upset, but in clinical trials, such as one we conducted in infants, side effects are rarely seen.

So why don’t we use it more widely?

No application has been made to bring OM85 to Australia. We are a small market not necessarily attractive to drug manufacturers.

In countries where OM85 is available, doctors can prescribe it but people can also buy it over the counter, in the same way they might a complementary medicine or health food supplement.

Research shows OM85 can reduce the risk of severe respiratory infections in children.
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OM85 has attracted plenty of scepticism in its time, with some people regarding it as “snake oil”.

Scientists are sceptical when we don’t understand why something works, or at least where we don’t have a plausible explanation for how it works. The idea something swallowed but not absorbed could protect the lungs sounds fanciful, especially without solid explanations.

But as we start to understand more about the mechanisms that may explain how OM85 works in the body, and with the accumulating clinical evidence, we have good reason to be open to and further explore its potential.

What we’ll do in the trial

Health-care workers are susceptible to severe respiratory respiratory infections associated with other viruses, including influenza, that can cause them to miss work.

We plan to give 1,000 health-care workers OM85, half immediately and half delayed by three months.

To understand how OM85 works we will collect blood samples and test immune responses.

We will determine which virus caused the respiratory illnesses if illness occurs (COVID-19 or other), whether the immune response is different depending on the virus, and whether OM85 is equally effective against all respiratory viruses encountered.

The trial is due to start this month and first results should be available by November.

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Read more:
The fascinating history of clinical trials

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Peter Sly, Director, Children’s Health and Environment Program and World Health Organization Collaborating Centre for Children’s Health and Environment, The University of Queensland

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Lao Officials to Expel More Christian Families from Village

Katin chief says previously expelled Christians will be shot if they return.

DUBLIN, November 9 (CDN) — Officials in Katin village, southern Laos have ordered six more Christian families to renounce their faith or face expulsion in early January, advocacy group Human Rights Watch for Lao Religious Freedom (HRWLRF) reported today (Nov. 9).

The Katin chief and the village religious affairs officer, along with local security forces, recently approached the six families with the threat after having expelled 11 Christian families, totaling 48 people, at gunpoint last January. The six families now under threat had become Christians since the January expulsion.

The eviction last January followed months of threats and harassment, including the confiscation of livestock and other property, the detention of 80 men, women and children in a school compound and the death by asphyxiation of a Christian villager. (See http://www.compassdirect.org, “Lao officials Force Christians from Worship at Gunpoint,” Feb. 8.)

Immediately after the expulsion, two more families in Katin village became Christians despite the obvious risk to their personal safety, according to HRWLRF. The village chief allowed them to remain in Katin but warned all villagers that their own homes would be “torn down” if they made contact with the expelled Christians.

In the following months, the expelled villagers suffered from a lack of adequate shelter, food and water, leading to eye and skin infections, diarrhea, dehydration and even the death of one villager. Katin authorities also denied Christian children access to the village school. (See http://www.compassdirect.org, “Christians Expelled from Village Suffer Critical Illnesses,” May 14.)

District officials in early May gave the Christians permission to return to Katin and take rice from their family barns to prevent starvation, said another source on condition of anonymity. Some families then tried to cultivate their rice fields to avoid losing them completely, but the work was extremely difficult as authorities had confiscated their buffaloes, essential to agriculture in Laos.

 

Threat to Shoot

In July, officials from the Saravan provincial headquarters and the Ta-oyl district religious affairs office met with the evicted families in their shelters at the edge of the jungle and encouraged them to return to Katin, HRWLRF said.

The Christians agreed to return under five conditions: that authorities designate a Christian “zone” within Katin to avoid conflict with non-believers; that all forms of persecution end; that their children return to school; that Christians must be granted the right of burial in the village cemetery; and that the village award compensation for six homes destroyed in the January eviction.

When higher-level officials approached Katin leaders with these terms, village officials and local residents rejected them, insisting that they would only allow the Christians to return if they gave up their faith. The higher officials invoked Decree 92, a law guaranteeing the rights of religious minorities, but village heads said they would shoot every Christian who returned to Katin.

Shortly after this discussion took place, a further four families in Katin became Christians, according to HRWLRF.

A communist country, Laos is 1.5 percent Christian and 67 percent Buddhist, with the remainder unspecified. Article 6 and Article 30 of the Lao Constitution guarantee the right of Christians and other religious minorities to practice the religion of their choice without discrimination or penalty.

Report from Compass Direct News

Lao Christians Expelled from Village Suffer Critical Illnesses

One dead, two hospitalized; village chief threatens other residents.

DUBLIN, May 14 (CDN) — In spite of assurances of religious rights by officials in March, Lao Christians expelled from a village in Saravan Province in January are suffering from a prolonged lack of adequate food and clean water.

The lack of basic resources has led to diarrhea, dehydration, eye and skin infections, fainting and general weakness for the Christians expelled from Katin village, and one person has died, Human Rights Watch for Lao Religious Freedom (HRWLRF) reported.

A Christian who went by the single name of Ampheng died suddenly in April while praying for one of two other Christians who were hospitalized with illnesses caused by their living conditions, an HRWLRF spokesman told Compass. The exact cause and date of Ampheng’s death were not immediately known.

Expelled from their village at gunpoint on Jan. 18 for failing to renounce their faith, the 48 Christians were forced to build temporary shelters at the edge of the jungle, about six kilometers (nearly four miles) away from the village.

They have since survived on food found in the jungle and water from a hand-dug well that is unfit for cooking or drinking, sources told HRWLRF.

District officials in early May gave the Christians permission to return to Katin village and take rice from their family rice barns to prevent starvation, said another source on condition of anonymity.

In addition, some of the Christians have returned to tend their family rice fields, fearing that if the fields are completely abandoned they may lose the right to cultivate them next year. Water buffaloes essential for farm work, however, were confiscated in January along with the Christians’ homes and registration papers, according to HRWLRF.

When the Christians interred Ampheng at the local burial ground, district officials fined them for failing to produce the required proof of house registration, according to HRWLRF.

Katin’s village chief recently warned other residents that their personal possessions would be confiscated if they had any contact with the expelled Christians. If any family continued to maintain contact despite repeated warnings, their own homes would be torn down, the chief reportedly said.

Official reactions to the plight of the Christians have been mixed. In March, a delegation of provincial and district officials led by Gov. Khamboon Duangpanya visited the Christians at their jungle site and assured them of their legal right to embrace the faith of their choice and to live anywhere in the district.

Just days earlier, however, the district head, identified only as Bounma, summoned seven of the Christians to his office and said that he would not tolerate the existence of Christianity in areas under his control. (See “Lao Officials Visit Expelled Christians, Give Assurances,” March 19.)

High level officials failed to intervene last July when villagers seized a Christian identified only as Pew and poured rice wine down his throat, killing him by asphyxiation. Village officials later fined Pew’s family for erecting a cross on his grave, and then detained 80 Christians in a school compound, denying them food and pressuring them to renounce their faith.

The heads of 13 families then signed documents renouncing Christianity in order to protect their children, but most resumed attendance at worship meetings within a few months.

Provincial officials did call a meeting in September 2008 asking Katin authorities to respect Lao religious laws and allow the Christians freedom to worship, but their request was ignored.

A communist country, Laos is 1.5 percent Christian and 67 percent Buddhist, with the remainder unspecified. Article 6 and Article 30 of the Lao Constitution guarantees the right of Christians and other religious minorities to practice the religion of their choice without discrimination or penalty.

Report from Compass Direct News 

MEXICO: CHRISTIANS JAILED FOR ACTEAL MASSACRE WIN RELEASE

Supreme Court rules their rights were violated; violence threatened in Chiapas.

MEXICO CITY, Aug. 13 (Compass Direct News) – At least 20 men accused of participating in a massacre in Chiapas state in December 1997 left prison early this morning – amid concerns over threats of violence at their home communities near San Cristobal de las Casas – following a Supreme Court ruling yesterday that their convictions violated fundamental norms of justice.

The release of the 20 men, most of them evangelical Christians, came after Mexico’s Supreme Court ruled in a 4-1 decision that they had been convicted in unfair trials in which prosecutors fabricated testimony and illegally obtained evidence. Area evangelicals view the imprisoned Christians as caught between survivors clamoring for convictions and government police and military forces eager to shift blame away from their minions following the Dec. 22, 1997 killing of 45 civilians in Acteal village.

“Acteal is a double tragedy,” attorney Javier Cruz Angulo reportedly said after the ruling. “On the one hand you have an abominable massacre, and on the other more than 50 human beings imprisoned without proofs.”

The court will review the cases of another 31 men convicted in connection with the massacre, and six more will be given new trials, according to news reports.

The identities of those released were not immediately known. As 32 of those imprisoned for the crime were Christians and another 15 received Christ while in prison, most of the previous total of 57 prisoners are Christians.

“In prison, the majority of us converted to the Presbyterian faith,” Tomas Perez Mendez, 60, told El Universal before the Supreme Court decision; at press time it was not known if he was among those released.

He told the Mexican newspaper that he bears no resentment even though his imprisonment led to illnesses that contributed to the deaths of family members. “My wife is ill, my father and one brother died from sorrow at seeing us here in prison . . . I no longer feel anger or resentment against those who accused me, and I plan to preach.”

Authorities had told a total of 57 prisoners that they would be freed after their paperwork was reviewed, a source in Chiapas told Compass.

“Naturally, those prisoners who had been informed of their impending release last week are extremely disappointed, as well wondering if they will ever be released,” said the source, who requested anonymity.

Two brothers, Pablo and Juan Hernandez Perez, reportedly said that they have no home to return to; their house was burned to the ground while they were in prison. Another hoping for release, Javier Vazquez Luna, told El Universal he played no part in the crime, and that indeed his father was one of the victims of the massacre.

The Supreme Court justices stated that they were not ruling on the guilt or innocence of the men, only on the violation of due process.

“During the investigation, their constitutional rights were violated,” the court said in a statement. “The majority of cases … were based on the use of illegally obtained evidence.”

In recent months relatives of the imprisoned men ratcheted up citizen campaigns seeking their freedom, backed by many others. For several years Presbyterian churches have carried banners outside their buildings requesting justice for those wrongly convicted in the Acteal violence. The Chiapas government had said it could do nothing because the case was under federal jurisdiction.

Pressure to reopen the case has intensified each December with remembrances of the massacre. In spite of intense political pressure to the contrary, the Supreme Court finally agreed to review the facts.

Threats of Violence

Amid statements by survivors of the Acteal crime that tensions could heighten in the area – and a grim warning from a former leader of Las Abejas, a supposedly non-violent group sympathetic to rebel militants whose members were killed in the massacre – defense attorneys and family members of the released men appealed to authorities to provide security and guarantee social peace.

“A former leader of the Abejas made a public declaration that if the men returned to their homes, the Abejas would be waiting for them, and the released prisoners would be repaid for the pain they caused 12 years ago,” the Chiapas source told Compass. “Tensions exist, and with statements like he made, the government is nervous about letting the men return to their homes due to possible violence. At this point, there are still no violent actions, but the threat of an outbreak is real.”

At press time authorities had prevented the released men from returning to the Acteal area, keeping them in a hotel in Berriozabal after loading them onto a truck through a back door of the El Amate prison at 3:35 a.m., El Universal reported.

Initially the prison director refused to see the men’s lawyers when they arrived at El Amate prison in Chiapas near midnight with orders for their release, the Compass source said.

“When he finally relented and met with the lawyers, it was only under extreme pressure from the Mexico City lawyers who refused to be dissuaded,” the source said. “There was an extended time of wrangling before the warden eventually released the prisoners, only under threat of returning to the Supreme Court and the Human Rights Commission about his intransigence.”

The released men had been promised there would be a government-paid bus waiting to take them to San Cristobal de las Casas, he said, but instead they were taken to the hotel in Berriozabal.

“The men were to meet with government officials today in Tuxtla, and we are still awaiting word on their arrival in San Cristobal after some five hours of waiting,” the source said. “It appears there are delaying tactics, hindrances and lack of cooperation in the entire release process.”

Some of the released men were able to meet with family members, and most expressed desire to return to the Acteal area, but the prison director said that authorities had determined that it was not safe for them to go back to their communities, according to El Universal. Authorities have reportedly proposed the possibility of providing them land parcels to avoid their returning to the area of the original conflict.

The evangelical Christians convicted were serving 25- or 36-year sentences and had exhausted all appeals. Some of them say they were arrested because rebel sympathizers with whom they had been embroiled in years of land disputes named them. Others said they were simply nearby when authorities made random round-ups.

Of the 34 men originally convicted, one died in prison and another had been released as a minor.

The family of one prisoner, Agustin Gomez Perez, tried to visit him in 2005. He told El Universal that they had an accident on the way, killing one small child and putting his wife in the hospital for 20 days – leaving their other five children without parents during that period.

Controversy over who killed the 45 people has revolved around whether there was a “massacre” by numerous “paramilitary” villagers or a “confrontation” between a handful of neighboring peasants and Zapatista National Liberation Army rebels. Historian Héctor Aguilar Camín has argued that there was both a confrontation and a massacre, with some overlap between each, but that they were largely separate incidents.

Five confessed killers have testified that they and four others engaged only Zapatista militia to avenge the death of a relative, while the federal attorney general’s office charged that at least 50 pro-government “paramilitaries” descended on a relief camp hermitage full of displaced peasants bent on killing and robbing them. The testimonies of the five confessed killers – four others remain at large – agree that the nine avengers were the only ones involved in the firefights, and that the decision to attack the Zapatistas was a private family decision made with no involvement from government authorities.

They also agree that the sole motive was to avenge the assassination of a relative – the latest of 18 unprosecuted murders by Zapatistas over the previous three months, according to Aguilar Camín.

Government prosecutors unduly dismissed much of the testimony of the five confessed avengers, Aguilar Camín wrote in a 2007 article for Nexos, noting that the killers testified that state security forces were nearby and did nothing. He highlights the judicial irregularities of the round-up and conviction of the peasants – apprehensions without evidence or warrant, charging 83 people with homicide when only 45 people were killed and lack of translators and attorneys for the suspects, Tzotzil Mayans who did not know Spanish.

The Supreme Court pointed out those violations in its ruling. Arturo Farela Gutierrez, head of the National Association of Evangelical Christian Churches, praised the court decision.

“We are in the presence of a court different from that of 12 years ago,” he said, according to El Universal. “The court is strengthened without fear of anything or anyone, and it’s the court that democratic Mexico needs.”

Report from Compass Direct News 

INDIA: SOLDIER PROTECTING CHRISTIANS MUTILATED, KILLED IN ORISSA

Two women whose houses were burned die from illnesses in hospital.

NEW DELHI, October 20 (Compass Direct News) – A paramilitary soldier assigned to protect Christians from Hindu violence in Kandhamal district, Orissa was mutilated and killed by a mob in Sisapanga village on Oct. 13.

The body of the Central Reserve Police Force (CRPF) soldier was recovered from a nearby forest. He was believed to have been hacked to death by tribal people in the wake of the worst anti-Christian violence in the history of modern India.

“Police recovered the body on Monday night – he has injuries on his torso and head,” District Superintendent of Police S. Praveen Kumar told national media. “It appears he was first beaten up by sticks and then killed by a sharp weapon.” Sisapanga village is under Raikia police jurisdiction.

“The soldier had been to Sisapanga village, accompanied by a driver, to buy provisions. A group of six-seven men attacked him from behind, dragged him into the jungle and hacked him to death,” Kumar told the Times of India (TOI). “The driver fortunately managed to escape.”

The death marks the first time that central security personnel have been targeted in Orissa in the riots that have raged since Hindu extremists insisted on blaming Christians for the Aug. 23 murder of Hindu leader Laxmanananda Saraswati, even though Maoists admitted killing him and four associates.

“The murder of the CRPF jawan [soldier] comes in the wake of persistent demands from the tribals to withdraw the paramilitary force,” a police spokesman told TOI. “The CRPF has made mass arrests, mostly of tribals, during the past two weeks.”

A local source who wished to be unnamed told Compass that the attackers have warned authorities through local media that they will carry out more killings of CRPF soldiers if the forces are not withdrawn.

 

Assurances, Assurances

Amid several assurances of protection by the state government, a mob demolished a Church of North India building on Oct. 11 in Sikuli village, Kalahandi district. The same day, the gang burned down two Christian houses in the village.

Two women who previously were driven from their homes when Hindu extremists set the structures on fire have died from illnesses. Minakshi Pradhan, 22, contracted malaria after fleeing to a refugee camp, later developing typhoid, and was admitted to MKCG Berhampur hospital, where she died on Thursday (Oct. 16).

“She has a 4-year-old child she left behind,” said a local source who wished to remain unnamed. Also survived by her husband, Anand Pradhan, Minakshi Pradhan was from Murudipanga village, Raikia block division, in Kandhmal district.

Another woman, Mili Pradhan, had a tumor detected in her stomach after her house was burned on Aug. 29, and she and husband Joshi Pradhan had to flee to Berhampur. Doctors operating on her detected blood cancer, and she died in the same hospital on Wednesday (Oct. 15.) She left behind an 18-month-old daughter.

Orissa Chief Minister Naveen Patnaik said in an interview to television channel NDTV that half of the 1,000-odd people arrested in the state for rioting belonged to the Hindu extremist Bajrang Dal and Vishwa Hindu Parishad (VHP). He added that he considered the Bajrang Dal a fundamentalist group.

In reaction, Subash Chouhan, national co-coordinator of the Bajrang Dal, said “It’s not the Bajrang Dal but Naveen Patnaik who is the real fundamentalist. . . . He is trying to show his secular character by trying to implement the Christian organizations’ agenda.”

Orissa police have arrested one of the “most wanted” in the anti-Christian riots in the state’s Kandhmal district.

Manoj Pradhan, a key tribal leader, was reportedly arrested at a lodge in Berhampur on Wednesday (Oct. 15) night.

“While investigating the case, we are finding it to be one of the most complicated cases in the state,” Arun Ray, inspector general of police, told media. “The crime was planned much before. We have identified the perpetrators of the crime. We have arrested three people and are likely to arrest some more people in the near future.”

 

Raped Nun

In the rape of a nun shortly after the violence began, police have arrested Mitu Patnaik and also implicated Muna Ghadei and Saroj Ghadei. They were arrested at a mill in Kerala’s Palakkad district on Oct. 11.

Police had earlier arrested five men – Juria Pradhan, Kartik Pradhan, Biren Kumar Sahu and Tapas Kumar Patnaik on Oct. 3 and Santosh Pradhan on Oct. 7 for their alleged roles in the crime.

Orissa police sent Patnaik to Cuttack for DNA testing. The alleged rape of the 29-year-old woman took place at the building of a Non-Governmental Organization in Kanjamendi village in Kandhamal on Aug. 25.

The nun has refused to come forward to identify any of the suspects, though inspector general Ray told media they were hopeful of making their case.

“The nun must be very scared and disturbed,” he said. “If necessary, the trial of the case can be held in any other place in Orissa.”

The nun has expressed her disbelief by saying that she would not like to “meet” the state police that remained a mute witness of her predicament.

“The nun wrote from a hospital, as she is yet to recover from the shock,” Archbishop Raphael Cheenath reportedly said.

At the same time, Hindu radicals want to reintroduce a tribal law that would obligate a rape victim to marry the man who rapes her.

On Oct. 13, some 5,000 radical Hindu women demonstrated in K. Nuagaon demanding that “the victim marry her rapist in accordance with local tradition.”

 

Refugee Camp Conditions

“With around 3,000 people in one camp, public health is pathetic in refugee camps,” attorney B. D. Das told Compass. “There is an epidemic of malaria, and water-borne diseases are spreading rapidly.”

One local source told Compass, that excess people in the refugee camps are forced to go back to their homes.

“As their homes are burnt, a plastic tent along with 10 days ration (food supply) is given to them and they are sent away,” he said. “Those in the relief camps are still better off as they at least have food. Those sent back do not have income, shelter and food.”

Christian leaders are concerned with the unhygienic conditions of the camps and people dying due to inadequate facilities.

Dr. John Dayal, member of the National Integration Council, told Compass that the chief minister of Orissa admitted that at least 10,000 people are still in government-run refugee camps, and that tens of thousands are in the forests or have migrated to towns outside Kandhamal.

“The government has admitted 40 dead, though we have details of 59 men and women mercilessly killed in the seven weeks of unabated mayhem,” he said. “For us, peace would be when the last refugee is back in his home, secure in his faith, with a livelihood restored, his children’s future secured as it should be in a secular India.”

 

Forced Reconversions

On Oct. 12 a student association, the Kandhamal Chatra Sangharsa Samiti, called for a moratorium on conversions by Christians to honor Saraswati’s lifetime of work trying to halt Christian conversions.

Christians have been forced to reconvert to Hinduism, burn Bibles and prayer books, have their heads shaved and drink cow urine (for Hindu purification). They have been placed for days under the watchful eye of Hindu groups so that they do not have any contacts with their former co-religionists.

Attorney Das noted, “700 forcible reconversions have taken place in Kandhmal since the riots began.”

Hindu extremist groups denied ever having attempted to “reconvert” tribal people, many of whom were not Hindus in the first place. “Why should we do it?” Subhash Chouhan, national co-convenor of Bajrang Dal said to the Times of India. “The Christian churches and missionaries have let them down, and the natives are making a conscious choice to become Hindus. We don’t have a single office in Kandhamal.”

Dr. Dayal told Compass that he has been distressed that while the continuing anti-Christian violence in Kandhamal, Orissa, Karnataka was forcefully detailed by Christians as well as by leaders of leftist parties, and human rights activists, “there was no assurance forthcoming as to when the more than 50,000 internally displaced persons, refugees in their homeland, can return home without being forced at gunpoint by the Bajrang Dal to become Hindus.”

Report from Compass Direct News