COVID-19 isn’t the only infectious disease scientists are trying to find a vaccine for. Here are 3 others

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Danielle Stanisic, Griffith University and Johnson Mak, Griffith University

More than 28 million people around the world have now contracted COVID-19, and more than 900,000 people have died.

Research groups across the globe are rightly racing to find a vaccine to protect against SARS-CoV-2, the virus that causes COVID-19.

While it’s not surprising all eyes are on this vaccine race, COVID-19 isn’t the only disease for which scientists are currently trying to find a vaccine.

Let’s look at three others.

The big three

We regard malaria, tuberculosis and HIV/AIDS as the “big three” infectious diseases. Together they’re responsible for about 2.7 million deaths a year around the world. They disproportionately affect low- and middle-income countries.

Deaths from these three diseases could almost double over the next year as a result of disruptions to health care in the face of COVID-19.

This is a clear example of the indirect effects of an uncontrollable infectious disease. It also reminds us of the importance of vaccine research for the many other infectious parasites, viruses and bacteria that can cause disease and death.

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Creating a COVID-19 vaccine is only the first step. It’ll take years to manufacture and distribute

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Malaria: the parasite

Malaria is a parasitic disease transmitted through the bite of an infected mosquito. Common symptoms are flu-like: fever, headache, muscle aches and fatigue. If not treated promptly, malaria can lead to severe disease and death.

In 2018, nearly half of the world’s population was at risk from malaria. There were roughly 228 million cases and 405,000 deaths from the disease, mainly in children under five in sub-Saharan Africa.

Anti-malarial drugs are routinely used to treat and prevent malaria infection. But Plasmodium falciparum, the deadliest of the malaria parasites that can infect humans, has developed resistance against all drugs currently used to treat and prevent malaria. So we urgently need an effective vaccine.

Development of a malaria vaccine is complicated by the diverse forms, or life-cycle stages, of the parasite in the human host. The immune responses required to kill the parasite differ between these different stages. So malaria vaccine candidates typically target just one parasite stage.

Malaria is a mosquito-borne disease.
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British multinational pharmaceutical company GSK has licensed the world’s first malaria vaccine, Mosquirix. It targets the stage the parasite is at when the mosquito injects it.

Although it’s the only malaria vaccine candidate to successfully complete phase 3 trials, Mosquirix has only moderate effectiveness (less than 40%) which drops off rapidly after the final dose. So we need a more effective vaccine capable of inducing long-lasting immunity.

There are 20 other malaria vaccine candidates in advanced pre-clinical or clinical evaluation.

At the forefront of these is Sanaria’s whole sporozoite vaccine (PfSPZ), which also targets the parasite stage injected by the mosquito. It’s currently being evaluated for effectiveness in Africa.

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Tuberculosis: the bacterium

Globally, tuberculosis is the leading cause of death by a single infectious agent. It’s caused by a bacterium that spreads from person to person through the air and mainly affects the lungs.

Tuberculosis was responsible for 1.5 million deaths in 2018. About one-quarter of the world’s population has latent tuberculosis, which has no symptoms and is not infectious. But 5-15% of these people will go onto develop active, infectious disease.

Generally, tuberculosis can be effectively treated with antimicrobial drugs. But the emergence of multi-drug resistant tuberculosis is a major cause of death and a serious public health concern.

We do have one licensed vaccine for tuberculosis. The BCG vaccine was first used in 1921 and is usually administered to infants in countries with high tuberculosis prevalence. But the degree and duration of protection this vaccine offers is not enough to control the disease.

Scientists are working to develop prophylactic vaccines (to prevent infection from the outset) and post-exposure vaccines (to prevent disease progression in people with latent tuberculosis).

At least 14 tuberculosis vaccine candidates are in clinical trials, with promising results giving hope we might be able to get the disease under better control in years to come.

HIV/AIDS: the virus

Since the discovery of human immunodeficiency virus (HIV) in the 1980s, the disease has caused 33 million deaths — roughly 770,000 in 2019. Some 38 million people have HIV/AIDS worldwide.

There’s currently no cure or protective vaccine. While antiviral therapeutics can effectively control HIV, around 20% (7.6 million) of HIV-infected patients don’t have access to them.

There’s no vaccine yet for HIV/AIDS.
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Researchers are aiming to develop a protective vaccine against HIV. A major focus is developing broadly neutralising antibodies (antibodies that can attack different HIV strains) in HIV-infected patients.

Notably, researchers identifying and developing COVID-19 therapeutics have used significant expertise from HIV vaccine development.

For example, defining the structural details of SAR-CoV-2’s spike protein as a target for a COVID-19 vaccine, and identifying broadly neutralising antibodies from convalescent plasma as a potential treatment, are similar to strategies scientists working on HIV have used.

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Time and commitment

Beyond COVID-19 and the big three, there are many more conditions for which scientists are working to develop vaccines.

The current pandemic highlights the need for governments, NGOs and philanthropists to support this work — and scientific research more broadly.

Research on one type of disease can often accelerate the development of treatments for others. We’re seeing this in the quest for a COVID-19 vaccine.

Ultimately, COVID-19 has raised public awareness of the type of scientific challenges researchers encounter every day. There’s neither a silver bullet nor a shortcut in the development of a safe and effective vaccine.

Danielle Stanisic, Associate Research Leader, Institute for Glycomics, Griffith University and Johnson Mak, Professor, Institute of Glycomics, Griffith University

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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http://www.globalpost.com/dispatches/globalpost-blogs/chatter/how-reduce-hiv-zimbabwe-make-women-uglier

Christians Fear Civilian Casualties in Burma

Junta targets ethnic minority states as civil war looms.

CHIANG MAI, Thailand, December 8 (CDN) — Civilians in two ethnic minority states with large Christian populations fear their lives will be in danger as skirmishes between rebels and a Burmese junta bent on instilling Buddhist nationalism threaten to escalate into war.

“It is likely that the military junta will carry out a military offensive against ethnic armed groups now that the elections are over,” Nang Mya Naddy, ethnic program coordinator of the Democratic Voice of Burma radio program, told Compass.

Christians fear that full-scale civil war in Burma (also known as Myanmar) could result in either ethnic cleansing or total subjugation of minorities. Persecution of Christians in Burma is part of a wider campaign against ethnic minority tribes to create a uniform society in which the only accepted religion is Buddhism, according to the British daily Telegraph, citing a 2007 government memo circulated in Karen state giving instructions on how to drive Christians out of the state.

Independent media reports suggest that the possibility of a major clash between ethnic armies and government troops is highest in Kachin and Karen states. Burma’s ethnic minorities, who inhabit states along Burma’s border with Thailand, China and India, have been demanding independence or autonomy for decades.

There are an estimated 1.2 million people in Kachin state, of which around 1 million are Christian. About 40 percent of the 3.5 million people in Karen state are estimated to be Christian. The Burmese junta, dominated by an ethnic Burman Buddhist majority, also seems to be preparing for war in the predominantly Buddhist state of Shan.

The junta has blocked trade links and deployed troops in Karen state, where the Karen National Liberation Army has not been offered a truce.

“The refugees from Burma continue to flow into neighboring Thailand as fighting fails to die down in Karen state between Burmese government troops and breakaway forces of the Democratic Karen Buddhist Army [DKBA],” reported The Irrawaddy, a Chiang Mai, Thailand-based publication covering Burma and Southeast Asia. “The latest military action was reported early on Monday [Dec. 6] from Myawaddy Township, where the Metta Linn Myaing village was shelled by junta troops. More than a dozen artillery shells hit the area of the village, according to local sources.”

Around 1,200 refugees are living at a border patrol police base in Mahawan area in Tak Province’s Mae Sot district in Thailand, a Thai official told The Irrawaddy.

“Sadly, so far neither side in the recent fighting has shown much regard for the civilians caught in the crossfire,” Elaine Pearson, deputy Asia director at Human Rights Watch, told The Irrawaddy. “The situation in Karen state was further complicated when the Karen National Union (KNU) entered into the conflict in support of the DKBA breakaway forces.”

David Takapaw, vice chairman of the KNU, told The Irrawaddy, “We will not stop fighting if they [the Burmese army] insist on trying to deploy in our area.”

The junta perceives all Christians in ethnic minority states as insurgents, according to the pro-democracy Free Burma Rangers (FBR) relief aid group. The Burmese Army attacked a Christian village in Karen state four months ago, according to the FBR, and on July 23 burned all houses and the state’s largest church in Tha Dah Der village.

 

Saber-Rattling

To intensify its battle for control in ethnic minority states after its Nov. 7 election victory, the Burmese army has blocked sea and land routes to Karen and Kachin states, increased deployment of troops in areas controlled by rebel groups and transported ammunition in large quantities.

In 2008, Burma’s government ordered all armed groups under ceasefires to meld into the Border Guard Forces. Many rebel groups have refused to comply.

Although the election – the first in the last two decades – was held last month and the government released pro-democratic leader Aung San Suu Kyi, it is becoming clearer daily that the junta is in no mood to address grievances of the country’s ethnic minorities.

While rights groups around the world are calling for national reconciliation, the Burmese junta, whose proxy party, the Union Solidarity and Development Party, is likely to have a majority in parliament, is preparing for a military fight with ethnic minority rebels.

“The recent purchase by the State Peace and Development Council [SPDC] of 24 Russian military helicopters, as well as the establishment of new helicopter bases near the Salween River, suggests that the Tatmadaw, the name for the Burmese military, is gearing up for a ‘military solution’ to the ethnic issue,” noted an opinion piece in The Irrawaddy on Nov. 29.

One of the military’s main targets is the Kachin Independence Army (KIA).

The KIA has had a ceasefire agreement with the Burmese government since 1994, but “it has recently been broken, and we are waiting to see what will happen next – if we can reconcile or not,” a leader of the Kachin Women’s Association Thailand identified only as Shirley told Compass. “The KIA wants reconciliation with the SPDC [State Peace and Development Council, Burma’s junta-controlled regime], but the government hasn’t allowed Kachin political groups to participate in politics or in the recent election.”

Indirect negotiations for peace are underway now, she said, adding that she was unsure if the Kachin will be attacked or not. “The KIA is ready to fight back,” she said.

Media reports indicate that the likelihood of the Burmese regime attacking is greater than chances of it seeking reconciliation.

 

Kachin State

“The threat to the Kachin Independence Organization [KIO, armed wing of the KIA] has increased manifold with the Burmese military junta dispatching significant quantity of arms to Kachin state, northern Burma,” reported the independent online Kachin News Group (KNG).

The military has also ordered the KIO to close down all its branch liaison offices in northern Burma. Only the main liaison office in Kachin’s capital, Myitkyina, has been allowed to function, KNG added.

In addition, the junta has provided arms training to workers of an agriculture company it supports, Yuzana Co., “in preparation for civil war with the Kachin Independence Organization,” the news group reported. In October, the military provided “60 Chinese-made M-22 assault rifles, copies of the Russian AK-47” to Yuzana workers in the Hugawng Valley, according to KNG.

The Rangoon-based Yuzana Co. came to the Hugawng Valley in 2006 and “grabbed up about 400,000 acres from the ethnic Kachin people with assistance from the local Burmese military and administrative authorities,” KNG reported. “Since 2006, the company has transported thousands of Burman ethnics from southern Burma to the Hugawng Valley every year.”

Mizzima, a New-Delhi based news organization, reported that the KIO has urged businessmen in the northern Burma stronghold of Laiza to leave, given the high probability of military conflict. A KIO spokesperson told Mizzima that “fighting was likely to break out soon.”

KNG also reported on Dec. 2 that Burma’s military junta “has a secret mission” to spread HIV in Kachin state as part of an ethnic cleansing effort. “Beginning 1990, the junta has systematically dispatched HIV-infected sex workers from the Thai-Burma border to Kachin state, especially to the Hpakant jade mining city,” it reported.

Shirley of the Kachin Women’s Association Thailand said she was not sure if “ethnic cleansing” was the goal of the Burmese army, but that the junta did want to spread AIDS as well as sell drugs to the Kachin people.

“The SPDC does not allow the expansion of churches and took over church land in certain areas,” she said. “The construction of new churches is not allowed, and the Kachin people have to ask permission to organize religious meetings, which is a detriment to community-building activities since the church is the foundation for the community, with 85 percent of the population being Christians.”

 

Emulate Sri Lanka?

Christians also fear that the Burmese regime may emulate the Sri Lankan government’s recent war against the separatist Liberation Tigers of Tamil Eelam (LTTE). Rights groups say thousands of civilians were killed in Sri Lanka before its government claimed victory over the areas controlled by the Tamil Tigers.

But Htet Aung, election specialist for The Irrawaddy, told Compass that while the Burmese regime may use Sri Lanka’s military strategy, “the nature of armed conflicts and their historical contexts are different.”

“While Sri Lankan’s government faced LTTE alone, the junta is now facing several armed ethnic groups,” Aung said. “The junta, unlike Sri Lanka’s present government, is facing a strong democratic leadership by Aung San Suu Kyi.”

Tensions in ethnic states are far greater than has been reported, sources said. Shirley added that there are only a few channels of communication in Kachin state, and the suffering of civilians there often goes unreported.

The Burmese regime projects that close to 70 percent of the country’s population is ethnic Burman. Ethnic minorities dispute the claim, saying the figure is inflated to make a case for Burman Buddhist nationalism.

The new constitution, which will come into force with the first session of parliament, was passed through a referendum in May 2008 that was allegedly rigged. It provides for religious freedom but also empowers the military to curb it under various pretexts.

Article 34 states, “Every citizen is equally entitled to freedom of conscience and the right to freely profess and practice religion subject to public order, morality or health and to the other provisions of this Constitution.” Article 360 (a), however, says this freedom “shall not include any economic, financial, political or other secular activities that may be associated with religious practice,” apparently to bar religious groups from any lobbying or advocacy.

Further, Article 360 (b) goes on to say that the freedom “shall not debar the Union from enacting law for the purpose of public welfare and reform.”

Adds Article 364: “The abuse of religion for political purposes is forbidden. Moreover, any act which is intended or is likely to promote feelings of hatred, enmity or discord between racial or religious communities or sects is contrary to this Constitution. A law may be promulgated to punish such activity.”

Furthermore, Article 382 empowers “the Defense Forces personnel or members of the armed forces responsible to carry out peace and security” to “restrict or revoke” fundamental rights.

Report from Compass Direct News

Kyrgyzstan: Religious freedom survey, December 2009

In its survey analysis of freedom of religion or belief in Kyrgyzstan, Forum 18 News Service finds that the state continues to violate its commitments to implement freedom of religion or belief for all. Limitations on this fundamental freedom and other human rights have increased – in both law and practice – under President Kurmanbek Bakiev.

A harsh new Religion Law was adopted in 2009, despite international protests, and a similarly harsh new Law on Religious Education and Educational Institutions is being drafted. There are also plans for a new Law on Traditional Religions.

State actions, including banning unregistered religious activity and raids on meetings for worship, show little sign of either a willingness to implement human rights commitments, or an understanding that genuine security depends on genuine respect for human rights.

As a Baha’i put it to Forum 18: "Our country has so many urgent problems – poverty, the lack of medicine, AIDS, crime, corruption. Why don’t officials work on these instead of making life harder for religious believers?" Kyrgyzstan faces the UN Universal Periodic Review process in May 2010.

Report from the Christian Telegraph 

Massive ‘Reconversion’ Event in India Aimed at Christians

Hard-line cleric leads campaign in Maharashtra, ideological capital of Hindu nationalism.

MUMBAI, India, October 27 (CDN) — Hundreds of tribal Christians and adherents of aboriginal religion from villages in Maharashtra state were reportedly “reconverted” to Hinduism yesterday in the Mumbai suburb of Thane at a ceremony led by a Hindu nationalist cleric.

Swami Narendra Maharaj’s goal was to “reconvert” 6,000 Christians in the so-called purification ceremony, reported The Hindustan Times, which put the number of “reconversions” at around 800. Hindu nationalists believe all Indians are born Hindu and therefore regard acceptance of Hinduism by those practicing other religions as “reconversion.”

Maharaj, a Hindu cleric known for opposing proclamation of Christ, has allegedly led anti-Christian attacks in tribal regions. On March 15, 2008, his men reportedly attacked two Catholic nuns, Sister Marceline and Sister Philomena, from the non-profit Jeevan Jyoti Kendra (Light of Life Center) in Sahanughati, near Mumbai.

The attack took place in a camp to educate tribal women on HIV/AIDS, which also provided information on government welfare programs, according to Indo-Asian News Service. The assault in Sahanughati, Alibaug district was followed by a mass “reconversion” ceremony in the area on April 27, 2008, said Ram Puniyani, a well-known civil rights activist in Mumbai.

Rightwing Hindu groups are mostly active in tribal areas. Hindu nationalists attack Christians in tribal areas because they provide social and development services, regarded as competition by rightwing Hindus seeking to woo tribal voters, said Anwar Rajan, secretary of the People’s Union of Civil Liberties (PUCL) in Maharashtra’s Pune city.

Kandhamal district in the eastern state of Orissa, where a massive spate of anti-Christian attacks took place in August-September 2008, is also a tribal-majority area. At least 100 Christians were killed, 4,600 houses and churches were burned, and over 50,000 people were rendered homeless in the violence.

Sociologists maintain that India’s tribal peoples are not Hindus but practice their own ethnic faiths. Hindu nationalists run Ekal Vidyalayas (one-teacher schools) in tribal regions to “Hinduize” local villagers and repel conversions to other faiths. These schools are operating in over 27,000 villages of India.

Dubious Claims

An anonymous spokesman of Maharaj said the plan for yesterday’s event was to “reconvert” 6,000 Christians to achieve the larger goal of “bringing back” 100,000 Christians, according to the Press Trust of India (PTI) news agency.

The rightwing spokesman in Maharashtra, a western state where Hindu nationalism originated decades ago, claimed that Maharaj and his followers had overseen the conversion of more than 94,000 Christians “back to their original faith” and plan to complete the target of 100,000 in the next two years.

Maharaj, whose followers call him Jagat Guru (Guru of the World), told PTI that those who “reconverted” were not coerced.

“We are not having a religious conversion here – it’s a process of purification,” Maharaj was quoted as saying. “We taught them the precepts of the Hindu religion, and they decided to convert to Hinduism on their own after repentance. They were not forced.”

Many reports of “reconversions,” however, have been found to be false.

In 2007, Hindi-language daily Punjab Kesari reported that four Christian families in Nahan town, in the northern state of Himachal Pradesh, had “reconverted” to Hinduism. But a fact-finding team of the All India Christian Council revealed that none of the members of those families had ever converted to Christianity.

The Hindustan Times reported yesterday’s ceremony included rituals involving cow’s milk, seeking forgiveness from ancestors, installation of idols of the Hindu gods Ganesh and Vishnu, and an offering ritual performed by priests from Ayodhya, in the northern state of Uttar Pradesh. Ayodhya is believed to be the birthplace of the Hindu god Rama.

Home of Hindu Nationalism

The basic philosophy of Hindu nationalism was expounded by Vinayak Damodar Savarkar, popularly known as Veer Savarkar, in 1923 through the publishing of a pamphlet, “Hindutva: Who is a Hindu?” Savarkar, who is from Maharashtra, argued that only those who have their ancestors from India as well as consider India as their holy land should have full citizenship rights.

A follower of Savarkar, Madhav Sadashiv Golwalkar, also from Maharashtra, further developed the Hindu nationalist philosophy through a book, “A Bunch of Thoughts,” in 1966. He claimed superiority of Hinduism over other religions and cultures of the world.

“In this land, Hindus have been the owners, Parsis and Jews the guests, and Muslims and Christians the dacoits [bandits],” he said.

The emergence of Hindu nationalist ideology from Maharashtra came in reaction to the politics of social justice by Dr. Bhim Rao Ambedkar and Mahatma (Jyotirao) Phule, said Irfan Engineer, director of the Institute of Peace and Conflict Studies in Mumbai and an expert on religious conflicts. Phule led a mass movement of emancipation of lower castes, mainly Shudras and Ati-Shudras or Dalits, in the 1870s. Ambedkar, known as the architect of the Indian Constitution, began movements against “untouchability” in the 1920s.

Also born in Maharashtra was the Rashtriya Swayamsevak Sangh (National Volunteer Corps, or RSS), India’s most influential Hindu nationalist conglomerate. It was founded in 1925 in Nagpur by Dr. K.B. Hedgewar.

Hindu society has traditionally had four castes or social classes, namely Brahmin, Kshatriya, Vaishya and Shudra. While Shudras belong to the lowest caste, Dalits were formerly known as “untouchables” because the priestly Brahmin class considered them to be outside the confines of the caste system.

During British colonial rule in the Indian subcontinent between 1858 and 1947, sections of the Brahmins felt the British were sympathetic towards the Dalit reformist movement, said Engineer of the Institute of Peace and Conflict Studies. Mahars, Maharashtra’s largest Dalit people group, have been very organized and powerful since then.

The PUCL’s Rajan said that the Brahmins have long portrayed minorities as enemies of Hinduism.

“Since the Dalit reformist movement is essentially against the Brahmin hegemony, the Brahmins had to react and get organized,” Rajan said. “As a part of their strategy to weaken the reformist movement, Brahmins projected minorities as the ‘real’ enemies of all Hindus, including Dalits and other lower castes, diverting attention away from the atrocities they meted out on them.”

Most of the founding leaders of Hindu nationalism, including Savarkar, Hedgewar and Golwalkar, were Brahmins. Since communal troubles benefited Hindu nationalists politically, the use of divisive issues became routine for them, Rajan added.

After two successive defeats of the Bharatiya Janata Party, political wing of the RSS, in general elections in 2004 and 2009, differences between the moderate and extremist sections within the Hindu nationalist movement – which blame each other for the party’s downfall – have deepened to unprecedented levels.

In frustration, the extremists have accelerated their activities, especially in Maharashtra, the ideological capital, said Dr. Suresh Khairnar, a well-known civil activist from Nagpur.

Report from Compass Direct News