Novavax is absent from Australia’s 2021 vaccination schedule. But it could be a useful booster later on

Cassandra Berry, Murdoch UniversityNovavax recently released excellent results from phase 3 clinical trials, finding its COVID-19 vaccine demonstrated 90.4% efficacy overall after two doses given three weeks apart.

The results, from close to 30,000 people in the United States and Mexico, found the vaccine demonstrated 100% protection against moderate and severe COVID-19, and was highly protective against circulating variants of interest and concern. It also has a good safety profile.

It’s important to note these results came directly from Novavax in a press release, and we’re still waiting to see the data published in a peer-reviewed journal. Once this happens, it’s likely Novavax will apply for approval from medical regulators around the world.

But this process will take a few months. The Therapeutic Goods Administration has said it doesn’t expect to receive the final data it needs to approve the vaccine until September. And in the COVID Vaccination Allocation Horizons, information the government released this week setting out vaccine allocation until the end of 2021, Novavax is not mentioned.

So by the time Australia is ready to deliver Novavax — the country has 51 million doses on order — we may well have completed most of the vaccine rollout with the AstraZeneca, Pfizer and Moderna vaccines. The situation will be similar in other countries, such as the United States.

However, that doesn’t mean Novavax won’t play an important role in Australia’s fight against COVID-19.

How does Novavax work?

Novavax is designed using protein-based technology. This is different from the AstraZeneca vaccine, which is a viral vector vaccine, and Pfizer and Moderna, which use mRNA technology.

Novavax works by introducing a part of the SARS-CoV-2 virus — the spike protein — to the immune system. The spike protein used is made in insect cells and doesn’t contain any live components of the virus. It can’t replicate or cause COVID-19.

To help the vaccine generate a stronger protective response, it uses an adjuvant, which is a molecule that boosts the immune system. The adjuvant Novavax uses is based on saponin, a natural extract from the Chilean soapbark tree.

COVID-19 vaccines work by targeting the spike protein, a protein on the surface of SARS-CoV-2.
Shutterstock

In some countries, Novavax could be used as an initial COVID vaccine. It will be relatively easy to distribute because it can be stored at regular fridge temperatures.

In other countries where most people will have already received two vaccine doses by the time Novavax becomes available, the vaccine could be used as an annual booster — on its own or as a supplement in formulated vaccines.

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Read more:
What is Novavax, Australia’s third COVID vaccine option? And when will we get it?

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A potential booster

Let’s say you’re writing a book. You write your first draft — that’s the first dose of vaccine. Then you edit and refine the final draft — that’s the second dose. You could say annual booster vaccines are like updated editions. Perhaps the original book is also translated into different languages, just as boosters could cover viral variants around the world.

In slightly more scientific terms, after the first vaccine dose, certain cells in our immune system (normal B cells) are activated and produce a primary antibody response. After the second vaccine dose, a slightly different flavour of immune cells (memory B cells) mount a stronger antibody response more rapidly.

But this immune memory can wane over time. Boosters may be needed to enhance immune memory responses to the SARS-CoV-2 spike protein in people who have previously been vaccinated against COVID-19.

Boosters could also be important as new variants emerge. Vaccines can often be reformulated to protect against new viral variants when original formulations aren’t working as well.

So even if Novavax isn’t the first or second COVID vaccine in our arms, it could be an important tool in our arsenal as we continue to navigate the pandemic.

Novavax could potentially be used as a booster vaccine down the track.
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What about in combination with the flu shot?

Novavax has recently revealed the efficacy of its COVID vaccine was roughly the same in a study where an influenza vaccine was administered simultaneously. This data, although yet to be peer-reviewed, signals Novavax could potentially be given alongside the annual flu shot.

In the future, we could even have the flu shot and Novavax combined in one vaccine. Novavax has designed and is currently testing a vaccine which combines SARS-CoV-2 and influenza spike proteins (called a multivalent vaccine).

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Read more:
Can I get AstraZeneca now and Pfizer later? Why mixing and matching COVID vaccines could help solve many rollout problems

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SARS-CoV-2 is rapidly evolving and we need to future-proof Australia against viral variants. As our knowledge of COVID-19 builds, we must develop strategies for more robust protection.

Rather than a fast sprint, our immune systems likely need to be primed for an ultra-marathon. Thinking about vaccines beyond the “first wave” of vaccination will be key.

Cassandra Berry, Professor of Viral Immunology, Murdoch University

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Lawyer Calls Turkish Christians’ Trial a ‘Scandal’

Evidence still absent in case for ‘insulting Turkishness and Islam.’

SILIVRI, Turkey, October 16 (CDN) — After three prosecution witnesses testified yesterday that they didn’t even know two Christians on trial for “insulting Turkishness and Islam,” a defense lawyer called the trial a “scandal.”

Speaking after yesterday’s hearing in the drawn-out trial, defense attorney Haydar Polat said the case’s initial acceptance by a state prosecutor in northwestern Turkey was based only on a written accusation from the local gendarmerie headquarters unaccompanied by any documentation.

“It’s a scandal,” Polat said. “It was a plot, a planned one, but a very unsuccessful plot, as there is no evidence.”

Turkish Christians Hakan Tastan and Turan Topal were arrested in October 2006; after a two-day investigation they were charged with allegedly slandering Turkishness and Islam while talking about their faith with three young men in Silivri, an hour’s drive west of Istanbul.

Even the three prosecution witnesses who appeared to testify at Thursday’s (Oct. 15) hearing failed to produce any evidence whatsoever against Tastan and Topal, who could be jailed for up to two years if convicted on three separate charges.

Yesterday’s three witnesses, all employed as office personnel for various court departments in Istanbul, testified that they had never met or heard of the two Christians on trial. The two court employees who had requested New Testaments testified that they had initiated the request themselves.

The first witness, a bailiff in a Petty Offenses Court in Istanbul for the past 28 years, declared he did not know the defendants or anyone else in the courtroom.

But he admitted that he had responded to a newspaper ad about 10 years ago to request a free New Testament. After telephoning the number to give his address, he said, the book arrived in the mail and is still in his home.

He also said he had never heard of the church mentioned in the indictment, although he had once gone to a wedding in a church in Istanbul’s Balikpazari district, where a large Armenian Orthodox church is located.

“This is the extent of what I know about this subject,” he concluded.

Fidgeting nervously, a second witness stated, “I am not at all acquainted with the defendants, nor do I know any of these participants. I was not a witness to any one of the matters in the indictment. I just go back and forth to my work at the Istanbul State Prosecutors’ office.”

The third person to testify reiterated that he also had no acquaintance with the defendants or anyone in the courtroom. But he stated under questioning that he had entered a website on the Internet some five or six years ago that offered a free New Testament.

“I don’t know or remember the website’s name or contents,” the witness said, “but after checking the box I was asked for some of my identity details, birth date, job, cell phone – I don’t remember exactly what.”

Noting that many shops and markets asked for the same kind of information, the witness said, “I don’t see any harm in that,” adding that he would not be an open person if he tried to hide all his personal details.

For the next hearing set for Jan. 28, 2010, the court has repeated its summons to three more prosecution witnesses who failed to appear yesterday: a woman employed in Istanbul’s security police headquarters and two armed forces personnel whose whereabouts had not yet been confirmed by the population bureau.

Case ‘Demands Acquittal’

Polat said after the hearing that even though the Justice Ministry gave permission in February for the case to continue under Turkey’s controversial Article 301, a loosely-defined law that criminalizes insulting the Turkish nation, “in my opinion the documents gathered in the file demand an acquittal.”

“There is no information, no document, no details, nothing,” Polat said. “There is just a video, showing the named people together, but what they are saying cannot be heard. It was shot in an open area, not a secret place, and there is no indication it was under any pressure.”

But prosecution lawyer Murat Inan told Compass, “Of course there is evidence. That’s why the Justice Ministry continued the case. This is a large ‘orgut’ [a term connoting an illegal and armed organization], and they need to be stopped from doing this propaganda here.”

At the close of the hearing, Inan told the court that there were missing issues concerning the judicial legality and activities of the “Bible research center” linked with the defendants that needed to be examined and exposed.

Turkish press were conspicuously absent at yesterday’s hearing, and except for one representative of the Turkish Protestant churches, there were no observers present.

The first seven hearings in the trial had been mobbed by dozens of TV and print journalists, focused on ultranationalist lawyer Kemal Kerincsiz, who led a seven-member legal team for the prosecution.

But since the January 2008 jailing of Kerincsiz and Sevgi Erenerol, who had accompanied him to all the Silivri trials, Turkish media interest in the case has dwindled. The two are alleged co-conspirators in the massive Ergenekon cabal accused of planning to overthrow the Turkish government.

This week the European Commission’s new “Turkey 2009 Progress Report” spelled out concerns about the problems of Turkey’s non-Muslim communities.

“Missionaries are widely perceived as a threat to the integrity of the country and to the Muslim religion,” the Oct. 14 report stated. “Further efforts are needed to create an environment conducive to full respect of freedom of religion in particular.”

In specific reference to Tastan and Topal’s case, the report noted: “A court case against two missionaries in Silivri continued; it was also expanded after the Ministry of Justice allowed judicial proceedings under Article 301 of the Criminal Code.”

The Turkish constitution guarantees freedom of religion to all its citizens, and the nation’s legal codes specifically protect missionary activities.

“I trust our laws on this. But psychologically, our judges and prosecutors are not ready to implement this yet,” Polat said. “They look at Christian missionaries from their own viewpoint; they aren’t able to look at them in a balanced way.”

Report from Compass Direct News 

Sodom found? The quest for the lost city of destruction – Part 2

By Brian Nixon, special to ASSIST News Service

Dr. Steven Collins, the unassuming archeologist from New Mexico, was at a crossroad. The site he was helping to excavate in the West Bank (Ai) from 1995-2000 closed down due to warfare and political maneuvering in the region. Steve, and project director Bryant Wood, had to close up shop.

“I didn’t know what to do,” he told me in a recent interview. “For the past five years, my life had been consumed by this dig. Then it was gone. I was dumbfounded.”

But this closed door proved to be an opening for something more amazing.

“It was then that I decided to conduct some research on a thought I had in 1996. During an archeology tour, I found that the traditional site for Sodom (known as the “Southern Theory”) didn’t match the geographical profile as described in Genesis 13-19.”

“As I began to research it more, and read through Genesis 13-19 several times, I had a thought that I had to pursue: they have the wrong location.”

“Many think Sodom is in the South (modeled after the famous archeologist, William F. Albright’s views), but the text seems to indicate that the site is in the Northeast,” he continued.

As “Indiana Jones” as Steve’s thoughts were, the conclusions and findings could be even more monumental than any blockbuster movie.

Essentially, Steve took the literal text of Genesis 13-19 and created a theoretical map, using the research methodology of Dr. Peter Briggs. This “map” utilizes a scientific approach to determine the validity of ancient texts. The conclusion? The texts in Genesis are reliable geographical indicators.

Working with Briggs, Collins developed a theory that the location was not in the Southern region, but in the Northeast.

From there, Dr. Collins began to flesh out his thoughts in a formal paper. This 250-page research paper was highlighted at the Near-Eastern Society Conference.

In his research, Collins focused in on five key areas: the geographical indicators, the chronological indicators, the terms of the destruction, the architecture and pottery, and the facts themselves.

“What I didn’t want to do,” he said, “was trample down the well-worn theories of past commentators and scholars. Basically, I wanted the text to speak for itself.”

“At the NES meeting, I received favorable comments from men of whom I have the utmost respect. I knew we were on to something quite thrilling.”

The one thing left to do was further research and the beginning of a dig.

“So my wife, a couple of students from Trinity Southwest University, and I headed off to Jordan to do research. We were in Jordan by 2002.”

“When I was doing research in the U.S., many of the maps and books were conspicuously absent of any detailed information regarding the north eastern region of the Dead Sea. Sadly, many of the scholars had ignored the text in Genesis.”

In Jordan, Collins found a host of helpful material.

“While in Jordan I found many maps, books, and archeological information at the American Center for Oriental Research library. In particular, a book by the journalist Rami Khouri, gave me the foundation I needed to get started.”

“Though this book was a popular work, it quoted from—and made reference to—many scholarly works. From that point on, we used Khouri’s book as a guide to the Jordanian literature on the sites north of the Dead Sea . We spent hours copying as much material as we could.”

“What we discovered seemed to coincide with our findings: Sodom was not in the south, it was northeast of the Dead Sea.”

“We were able to locate some information from one of the last major digs that occurred in the area. We also paid close attention to a 1975/1976 survey of the Jordan Valley. This survey stated that the area of our interest had many ancient sites.”

“So we headed off to the area northeast of the Dead Sea and began to look around. What we found amazed us. There were at least ten sites that could possibly be ancient Sodom.”

“Sodom is mentioned first in the Bible—consistently—thereby giving it prominence as the largest city in that area. So based upon the text and our previous research we chose the largest site. And let me tell you, this find at Tel-al-Hammam turned out to be much greater than we ever hoped for.”

Report from the Christian Telegraph

CHINA: BOOKSTORE OWNER SENTENCED TO THREE YEARS IN PRISON

Shi Weihan also fined nearly $22,000; ‘illegal business’ printed Bibles for free distribution.

 

LOS ANGELES, June 10

(Compass Direct News) – A Beijing court today found Christian bookstore owner Shi Weihan guilty of “illegal business operation” and sentenced him to three years in prison and a 150,000 yuan (US$21,975) fine.

Sources said Shi’s store operated legally and sold only books for which he had obtained government permission, and that his Holy Spirit Trading Co. printed Bibles and Christian literature without authorization but only for free distribution to local house churches.

The 38-year-old Shi had been released on Jan. 4, 2008 due to insufficient evidence for the same vague charge of “illegal business operation,” but he was arrested again two month later, on March 19, and held virtually incommunicado. Contrary to Chinese law, authorities have denied all but a few visits from his lawyer and family, held him without charges for most of his time in jail, and initially withheld medication for his diabetes.

The court ruling appears to have allowed time that Shi has spent in jail to count toward his sentence, a source said, as his prison term was described as running from Nov. 28, 2007, when he was initially arrested, to Nov. 27, 2010.

Others in a printing company who stood trial with Shi appeared to have received similar sentences. A written judgment is expected within 15 days to allow time for an appeal to be filed, said Ray Sharpe, a friend of Shi.

“Absent an appeal, it is also possible that Shi could be allowed a sort of medical parole, due to his diabetic condition,” Sharpe said. “Hopefully, he could then be allowed to stay in a hospital under a sort of house arrest.”

He said that Shi did not yet know whether he would appeal, adding that the process could take up to a year.

Friends and business acquaintances of Shi have described him as a model citizen of China, saying that he has inspired them to love China by his patriotism and love for his homeland. They said he is known for selfless sacrifice on behalf of poor and disenfranchised rural Christians and minority children.

For much of his incarceration, Shi’s wife Zhang Jing and their two daughters, 12-year-old Shi Jia and 8-year-old Shi En Mei, have not known where he was being held. The family has been under nearly continual surveillance, limiting their ability to make contact with people who could assist them.

Sources said Zhang has worried about her husband’s condition and that she has taken on leadership duties at their church, where Public Security Bureau officials have intimidated the congregation with regular visits. Some members have left the church because of the intimidation, sources said, and Zhang is said to have suffered anxiety and stress that have led to depression.

Their two daughters have been ostracized at school for being the children of a prisoner, sources said.

Shi has lost more than 44 pounds since his second incarceration, they said, dropping to less than 130 pounds. The sources added that he has suffered from blisters because of unsanitary conditions in prison, as well as tinnitus that at times causes his ears to ring so loudly that he cannot sleep.

Chinese officials claim that the Nanjing Amity Printing Co. (Amity Press), the only government-approved Bible publisher, produces enough Bibles to meet the needs of the Chinese church, which various religious freedom organizations dispute. The groups complain that Amity prints a large share of its Bibles for export, and those sold domestically are not available to many Christians.

Report from Compass Direct News

56 RELIGIOUS ORGANISATIONS OFFICIALLY SCHEDULED FOR LIQUIDATION IN RUSSIA

On 15 October, a declaration unexpectedly appeared on the webpage of the Russian Ministry of Justice listing 56 religious organisations scheduled for liquidation. These stem from a number of major world faiths and included Buddhists, Jews, Muslims, the Catholic “Caritas” as well as small, dissident Orthodox groups and one organisation belonging to the Kiev Orthodox Patriarchate, reports William Yoder, Russian Union of Evangelical Christians-Baptists. Yet at least 35 of the 56 listed qualify as Protestant organizations. These include the humanitarian “World Vision” and “Youth with a Mission”. At least six Baptist organizations are listed. These include one established by the Russian branch of the “Billy Graham Evangelistic Association” and three regional districts of the “Russian Union of Evangelical Christians-Baptists” (RUECB). Apparently; several entire churches are up for liquidation, including the “Union of Churches of Presbyterian Christians” and the “Assemblies of God”. Even the 26-congregation-strong “Union of Churches of Evangelical Christians” is scheduled for elimination. Its Bishop, businessman Alexander Semchenko, remains a member of the presti gious “Council for Cooperation with Religious Organisations at the Seat of the Russian President”.

Pastor Vitaly Vlasenko, the RUECB’s Director for External Church Relations, warns against undue alarm, for the declaration states only that the Justice Department “plans to file liquidation claims” against the 56. “This is a wake-up call,” the Pastor adds. “This is certainly not the last word on the matter.” He reports that thousands of religious organisa tions were registered during the 1990s, and that a number of them are now virtually defunct. Many have failed to submit the annual reports on activities and finance demanded by Russian law. In some cases, registered and factual activities no longer match. In one instance, a Baptist organization registered in Moscow is active only in Siberia.

Attorney Anatoly Pchelintsev from Moscow’s „Slavic Centre for Law and Justice” (SCLC) sees serious injustice in the fact that the Russian Orthodox Church Moscow Patriarchate is absent from the list. Due to its overpowering size, the law of averages would demand that a least a few of its organisations find their way onto the list. Yet Protestants, who speak for less than 1% of the Russian population, make up 62% of the total list. He sees no regard for the appropriateness of means, describing liquidation as akin to meting out the death penalty to persons found guilty of jaywalking. “Such actions fly in the face of official Russian state policy on the freedom of worship and creed.” Pchelin tsev, a seasoned legal veteran, believes the responsible officials are hardly aware of the complicated international ramifications of their own decree and cites the possibility of “chaos and destabilisation in church-state relations”.

In June, the highly-active SCLJ succeeded in getting a decision requiring the liquidation of a 30-member Methodist congregation in Smolensk overturned. Two years ago, it won a Euro pean Court ruling in Strasbourg sentencing the Russian Federation to a fine for having forbidden the work of the Salvation Army. The SCLJ was initially formed in 1993 and took on its present name when it became an affiliate of the Washington/DC-based “American Center for Law and Justice” (ACLJ) in 1998. The head of ACLJ is Jay Sekulow, America’s leading attorney on religious affairs. ACLJ was founded in 1990 by the controver sial Pat Robertson, a Southern Baptist and charismatic. He is probably America’s most prominent television preacher.

The RUECB, Russia’s largest, unified Protestant church, represents approximately 80.000 adult members in 1.750 congregations and groups. Its President is Yuri Sipko.

Report from the Christian Telegraph